Key result
Cadherin-11 deficiency reduces Ang-II-induced atrial fibrosis and AF susceptibility in mice.
Why the study?
Cadherin-11 is essential in non-cardiac fibrotic diseases, but its role in the pathogenesis and underlying mechanism of atrial fibrillation was unknown.
Does CDH11 deficiency reduce Ang-II-induced atrial fibrosis and susceptibility to atrial fibrillation in mice?
Does CDH11 deficiency reduce Ang-II-induced atrial fibrosis and susceptibility to atrial fibrillation in mice?
CDH11 deficiency attenuates Ang-II-induced atrial fibrosis and susceptibility to atrial fibrillation, suggesting CDH11 as a potential therapeutic target.
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May identify CDH11 as AF target; leaves open translation to human disease.
Cao et al. (2021) studied Atrial fibrillation and atrial fibrosis. CDH11 knockout vs. Normal mice was evaluated on Atrial fibrosis and susceptibility to atrial fibrillation. Cadherin-11 deficiency significantly attenuated Ang-II-induced atrial fibrosis and susceptibility to atrial fibrillation in mice.
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