Key result
Cadherin-11 deficiency mitigated high-fat diet-induced adverse atrial structural remodeling, inflammation, and fibrosis in mice, suggesting it as a potential target for obesity-related AF.
Why the study?
Obesity is closely linked to AF and Cad-11 contributes to diet-induced obesity, but whether Cad-11 influences atrial remodeling and AF vulnerability in diet-induced obesity was unknown.
Does Cadherin-11 deficiency mitigate high-fat diet-induced inflammatory atrial remodeling and vulnerability to atrial fibrillation in a diet-induced obesity model?
Does Cadherin-11 deficiency mitigate high-fat diet-induced inflammatory atrial remodeling and vulnerability to atrial fibrillation in a diet-induced obesity model?
Cadherin-11 deficiency mitigates high-fat diet-induced inflammatory atrial remodeling and AF vulnerability, highlighting it as a potential therapeutic target for obesity-related AF.
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May position Cadherin-11 as a target in obesity-related AF; leaves open translation from murine models to humans.
Fang et al. (2021) studied Atrial fibrillation and obesity. Cadherin-11 deficiency vs. Wild-type was evaluated on Atrial structural remodeling, inflammation, and fibrosis. Cadherin-11 deficiency mitigated high-fat diet-induced adverse atrial structural remodeling, inflammation, and fibrosis in mice, suggesting it as a potential target for obesity-related AF.
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