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December 4, 2025Nutrition & MetabolismOpen Access

High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction

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Authors

QWQiaona WangYWYong‐Fa WangYHYuefeng Hu

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Overview

Behavioral assessments reveal high-fructose diet induces depressive-like behaviors in mice, implying neurogenesis impairment and altered apoptosis pathways.

Key Points

  • Depressive-like behaviors were induced by high-fructose diet, impacting neurogenesis significantly.
  • Behavioral assessments included the tail suspension test and elevated plus maze for measuring anxiety and depression.
  • Analysis showed disrupted hippocampal neurogenesis linked to both apoptosis and ferroptosis, indicating broader metabolic issues.
  • Findings emphasize the neuropsychiatric risks associated with a high-fructose diet, highlighting the need for further research.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3ae9https://doi.org/10.1186/s12986-025-01043-7
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