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December 4, 2025DiagnosticsOpen Access

Line-Field Confocal Optical Coherence Tomography of Basal Cell Carcinoma: Systematic Correlation with Histopathology

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Authors

LBLucas BoussingaultUniversité Libre de BruxellesCLClement LenoirASAlessandro Di Stefani

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Overview

Objective analysis shows strong concordance with histopathology in basal cell carcinoma, suggesting reliability of non-invasive imaging methods.

Key Points

  • High concordance in diagnostic features for basal cell carcinoma was demonstrated with histopathology using line-field confocal optical coherence tomography.
  • The study showed ≥80% concordance for features like lobules and dermal-epidermal junction in basal cell carcinoma imaging.
  • Retrospective analysis of 127 confirmed basal cell carcinoma cases showcased objective and subjective assessments of imaging techniques.
  • Findings indicate that line-field confocal optical coherence tomography is beneficial for non-invasive diagnosis and management of basal cell carcinoma.

Cite This Study

Boussingault et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3b85https://doi.org/10.3390/diagnostics15233059
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Understanding the Dermoscopic Patterns of Basal Cell Carcinoma Using Line-Field Confocal Tomography2024 · 6 citations
  2. 2Ex Vivo Line-Field Confocal Optical Coherence Tomography and Ex Vivo Fusion Confocal Microscopy for Lateral-Margin Assessment of Basal Cell Carcinoma in Correlation with Histopathology: A Prospective Pilot Diagnostic-Accuracy Study2026
  3. 3Reflectance Confocal Microscopy Versus Line‐Field Confocal Optical Coherence Tomography in Facial and Scalp Lesions Suspicious for Basal Cell Carcinoma: A Histopathology‐Referenced Multi‐Reader Study2026
  4. 4Line‐field confocal optical coherence tomography and optical coherence tomography for distinguishing basal cell carcinoma from dermal nevus: A case report2024
  5. 5Systematic Review of Line-Field Confocal Optical Coherence Tomography for Diagnosing Pre-Malignant and Malignant Keratinocytic Lesions: Optimising the Workflow2025