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December 5, 2025Frontiers in Cell and Developmental BiologyOpen Access

Role of histone post-translational modifications in atherosclerosis and the therapeutic potential of targeting epigenetic modifiers

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Authors

LWLili Wu

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Overview

This review highlights therapeutic strategies targeting histone modifications in atherosclerosis, indicating their role in vascular dysfunction and gene expression.

Key Points

  • Atherosclerosis is linked to multiple histone post-translational modifications that drive vascular dysfunction.
  • Abnormal histone modifications disrupt gene expression, influencing cellular functions and promoting atherogenesis.
  • Therapeutic strategies targeting histone modifications aim to restore vascular cell homeostasis and improve outcomes.
  • The findings suggest a critical need for precision diagnostics focusing on epigenetics to treat cardiovascular diseases.

Cite This Study

Lili Wu (2025) studied this question.

synapsesocial.com/papers/693231118e51979591dce031https://doi.org/10.3389/fcell.2025.1705966
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