The role of substance P in Th17/Treg imbalance and ocular surface damage in chronic allergic conjunctivitis

Jiayu Bao; Ya Wen; Binge Wu; Yaqiong Li; Siyuan Li; Fengyang Lei; Lei Tian; Xiaoniao Chen; Ying－Jie

doi:10.1186/s12967-025-07460-9

December 1, 2025Journal of Translational MedicineOpen Access

The role of substance P in Th17/Treg imbalance and ocular surface damage in chronic allergic conjunctivitis

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Key Points

Substance P contributes to ocular surface damage through Th17/Treg imbalance.
Key metrics indicate disruption of signaling pathways leads to persistent allergic conjunctivitis.
Analysis of the SP/NK1R pathway provides insights into potential therapeutic approaches.
Findings may enable new treatment strategies to address chronic allergic conjunctivitis symptoms.

Implication

Observational analysis highlights Th17/Treg imbalance affecting ocular surface in chronic allergic conjunctivitis, suggesting a novel therapeutic approach.

Abstract

Substance P contributes to persistent AC by disrupting the Th17/Treg equilibrium via STAT3/STAT5 signaling, thereby exacerbating ocular surface damage. Targeting the SP/NK1R pathway may offer a novel therapeutic approach for chronic AC.

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Cite This Study

Bao et al. (2025) studied this question.

synapsesocial.com/papers/693231118e51979591dce124 https://doi.org/10.1186/s12967-025-07460-9

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The role of substance P in Th17/Treg imbalance and ocular surface damage in chronic allergic conjunctivitis

Key Points

Implication

Abstract

Discussion

Cite This Study

The role of substance P in Th17/Treg imbalance and ocular surface damage in chronic allergic conjunctivitis

Key Points

Implication

Abstract

Discussion

Cite This Study

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