The role of transmembrane proton transport rates in mild mitochondrial uncoupling by arylamide substituted fatty acids

Ethan Pacchini; Daniel A. McNaughton

doi:10.1039/d5sc06530e

January 1, 2025Chemical ScienceOpen Access

The role of transmembrane proton transport rates in mild mitochondrial uncoupling by arylamide substituted fatty acids

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Key Points

Mitochondrial uncoupling lowers energy efficiency and contributes to metabolic modulation, aiding obesity treatment.
Key evidence indicates that altered proton transport may enhance the effects of therapeutic agents targeting uncoupling agents.
Assessment using various fatty acids highlights the impact of arylamide substitutions on proton transport rates within mitochondria.
Findings imply that improved understanding of proton transport mechanisms could lead to better strategies for obesity, diabetes, and cancer therapies.

Implication

Observational analysis suggests proton transport influences mitochondrial uncoupling in obesity, indicating therapeutic potential for diabetes and cancer.

Abstract

Mitochondrial uncoupling by small molecule protonophores is a promising therapeutic strategy for leading diseases including obesity, diabetes and cancer, however the clinical potential of these agents is complicated by their...

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Cite This Study

Pacchini et al. (2025) studied this question.

synapsesocial.com/papers/69337cceb3f947a0a1259d28 https://doi.org/10.1039/d5sc06530e

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The role of transmembrane proton transport rates in mild mitochondrial uncoupling by arylamide substituted fatty acids

Key Points

Implication

Abstract

Discussion

Cite This Study

The role of transmembrane proton transport rates in mild mitochondrial uncoupling by arylamide substituted fatty acids

Key Points

Implication

Abstract

Discussion

Cite This Study

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