What question did this study set out to answer?

To evaluate mitochondrial proton cycling and uncoupling pathways as therapeutic targets to increase metabolic rate and treat obesity.

November 1, 2001Obesity Reviews

Mitochondrial uncoupling as a target for drug development for the treatment of obesity

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Authors

JHJames A. HarperAstraZeneca (United Kingdom)KDKeith DickinsonUniversity of Leeds MBMartin D. BrandUniversity of Maryland, Baltimore

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Implication

Review reveals pathways of mitochondrial uncoupling to increase energy expenditure in obesity, suggesting viable targets for antiobesity drug development.

Key Points

To evaluate mitochondrial proton cycling and uncoupling pathways as therapeutic targets to increase metabolic rate and treat obesity.
Narrative synthesis evaluating chemical, hormonal, and dietary mechanisms of mitochondrial uncoupling in vivo.
Analysis of specific molecular targets including uncoupling protein 1 (UCP1), UCP2, UCP3, and adenine nucleotide translocase in brown adipose tissue and skeletal muscle.
Mitochondrial proton cycling accounts for a significant fraction of basal metabolic rate, establishing uncoupling as a potent driver of energy expenditure.
Activation of UCP1 via direct stimulation or beta 3-adrenoceptor agonists in brown fat, along with modulation of UCP3 and adenine nucleotide translocase in muscle, presents high-potential antiobesity targets.
Historical mechanisms such as 2,4-dinitrophenol and thyroid hormone demonstrate substantial fat-loss efficacy through uncoupling, underscoring the therapeutic potential of tissue-specific modulators.

Cite This Study

Harper et al. (2001) studied this question.

synapsesocial.com/papers/6a0f3b1ea7a2fed64abdd6e9 https://doi.org/10.1046/j.1467-789x.2001.00043.x

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Implication

Review reveals pathways of mitochondrial uncoupling to increase energy expenditure in obesity, suggesting viable targets for antiobesity drug development.

Mitochondrial uncoupling as a target for drug development for the treatment of obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

Mitochondrial uncoupling as a target for drug development for the treatment of obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

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