December 6, 2025RSC PharmaceuticsOpen Access

Formulation and Evaluation of Isosorbide Dinitrate-Loaded Flash-Release Dispersible Sublingual Wafers

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This study demonstrates a novel sublingual formulation for Isosorbide Dinitrate, highlighting the potential of Quality by Design in drug delivery.

Sublingual wafers developed for fast absorption reduce the time needed for Isosorbide Dinitrate delivery.
The formulation utilizes lyophilisation to enhance drug stability and effectiveness in the body.
Under Quality by Design principles, this approach optimizes production while ensuring consistent quality.
This novel delivery system may improve therapeutic outcomes for conditions requiring rapid intervention.

M Kamath (2025) studied this question.

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This study demonstrates a novel sublingual formulation for Isosorbide Dinitrate, highlighting the potential of Quality by Design in drug delivery.