December 6, 2025Frontiers in MedicineOpen Access

Multidimensional study on mitochondrial dysfunction in pulmonary hypertension

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Review highlights mitochondrial dysfunction's impact on pulmonary hypertension, suggesting interventions to improve heart failure outcomes.

Mitochondrial dysfunction drives pulmonary hypertension progression and related heart failure.
Key mechanisms include mitochondrial DNA damage and electron transfer chain dysfunction.
Observational analysis of various cellular pathways related to metabolism and endothelial dysfunction.
Understanding mitochondrial dysfunction may enhance future therapeutic strategies for vascular remodeling.

Liu et al. (2025) studied this question.

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Review highlights mitochondrial dysfunction's impact on pulmonary hypertension, suggesting interventions to improve heart failure outcomes.