Key result
Metabolic theory proposes mitochondrial and metabolic dysfunction as major PH drivers offering new therapeutic targets.
Why the study?
The metabolic theory of pulmonary hypertension proposes metabolism and mitochondrial dysfunction as key causes, but the timing and extent of these changes remain unknown.
Population
Patients with pulmonary hypertension
Design
Review article
Authors
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Metabolic targeting in PH remains investigational; hypothesis-generating and requires prospective validation before clinical consideration.
This review highlights the emerging metabolic theory of pulmonary hypertension, suggesting that metabolic and mitochondrial aberrations may be a major underlying cause and a promising therapeutic target.
Frump et al. (2018) conducted a review in Pulmonary Arterial Hypertension. The metabolic theory of pulmonary hypertension proposes that aberrations in metabolism and mitochondrial function are a major underlying cause of the disease, offering new therapeutic targets.
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