Observational analysis shows enhanced treatment response and survival outcomes in high-risk rectal cancer with total neoadjuvant therapy, pointing to better organ preservation and therapeutic efficacy
In MRI-defined high-risk LARC patients, TNT could improve the survival trend while increasing the likelihood of organ preservation without exacerbating surgical complexity. These findings emphasize the fact that TNT should be prioritized for the high-risk MRI-defined population to achieve enhanced local tumor control, sustained therapeutic efficacy, and prolonged survival.
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Xia et al. (2025) studied this question.
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