What type of study is this?

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial, RCT).

December 8, 2025TrialsOpen Access

The clinical and cost effectiveness of a conservative treatment pathway compared to appendicectomy in children with uncomplicated acute appendicitis: study protocol for a randomised controlled multi-centre open-label parallel-group non-inferiority trial (CONTRACT 2 trial) in the United Kingdom (UK)

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Authors

NPNatalia Vadimovna Permyakova IRIsabel C Reading YBYoung Bridget

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Implication

Randomised controlled trial assesses clinical effectiveness and cost effectiveness in children with appendicitis, suggesting potential benefits of a conservative treatment pathway.

Key Points

Non-operative treatment pathway improves recovery while reducing complications for children with acute appendicitis.
Primary endpoint includes treatment success as a composite outcome measured at 1 year in 376 children.
Randomised controlled trial setup involves both qualitative and health economic evaluations across several UK hospitals.
This approach may highlight a safer and more cost-effective alternative than surgery for managing acute appendicitis.

Cite This Study

Permyakova et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c1a3 https://doi.org/10.1186/s13063-025-09282-y

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Implication

Randomised controlled trial assesses clinical effectiveness and cost effectiveness in children with appendicitis, suggesting potential benefits of a conservative treatment pathway.

The clinical and cost effectiveness of a conservative treatment pathway compared to appendicectomy in children with uncomplicated acute appendicitis: study protocol for a randomised controlled multi-centre open-label parallel-group non-inferiority trial (CONTRACT 2 trial) in the United Kingdom (UK)

Discussion

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Implication

Key Points

Cite This Study

The clinical and cost effectiveness of a conservative treatment pathway compared to appendicectomy in children with uncomplicated acute appendicitis: study protocol for a randomised controlled multi-centre open-label parallel-group non-inferiority trial (CONTRACT 2 trial) in the United Kingdom (UK)

Discussion

Member takes

Implication

Key Points

Cite This Study

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