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December 8, 2025Journal of Cellular PhysiologyOpen Access

Telomere Attrition‐Induced Senescence in Human Pluripotent Stem Cell‐Derived Astrocytes: Distinct Cellular and Functional Characteristics

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Authors

SOSeung Soo OhGYGyu‐Bum YeonJCJae‐Yeon Choi

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Overview

Study finds telomerase activity contributes to senescence and DNA damage in astrocytes, suggesting complex cellular interactions.

Key Points

  • Senescence markers appear in astrocytes without functional impairment, suggesting a transitional phase.
  • Treatment with telomerase inhibitor BIBR1532 reveals increased DNA damage and altered reactive oxygen species levels.
  • Analysis reveals that disrupted mitochondrial function does not equate to loss of key astrocytic functions.
  • Insights into the mechanisms of astrocytic senescence highlight the need for further exploration of cellular stress pathways.

Cite This Study

Oh et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c331https://doi.org/10.1002/jcp.70118
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