December 8, 2025Frontiers in PharmacologyOpen Access

Rhein ameliorates inflammation, gut dysbiosis, and renal injury in obesity-related glomerulopathy mice

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Authors

LLLijie LiUniversity of Science and Technology of China GLGe LiCentral South University

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Implication

Rhein shows improved renal function and gut microbiota diversity in C57BL/6J mice with obesity-related glomerulopathy, suggesting potential therapeutic benefits.

Key Points

Rhein significantly improved renal function by reducing inflammation and proteinuria in obesity-related glomerulopathy.
IL-6 levels decreased markedly, with glomerular lesions showing improvement in treated mice.
Assessment using 16S rRNA microbiome sequencing revealed a restored gut microbiota diversity following Rhein treatment.
These findings imply Rhein could offer a novel approach to manage obesity-related kidney disorders.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c3e9 https://doi.org/10.3389/fphar.2025.1654062

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Implication

Rhein shows improved renal function and gut microbiota diversity in C57BL/6J mice with obesity-related glomerulopathy, suggesting potential therapeutic benefits.

Rhein ameliorates inflammation, gut dysbiosis, and renal injury in obesity-related glomerulopathy mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Rhein ameliorates inflammation, gut dysbiosis, and renal injury in obesity-related glomerulopathy mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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