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December 8, 2025Archives of Disease in Childhood Fetal & NeonatalOpen Access

Influence of a rapid volume infusion during advanced cardiopulmonary resuscitation of severely asphyxic near-term lambs

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Authors

NTNhi T. TranRGRobert GalinskySHStuart B. Hooper

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Overview

Observational analysis boosted cerebral blood flow and mean blood pressure in near-term lambs, suggesting saline infusion may not enhance ROSC.

Key Points

  • Blood pressure and cerebral blood flow during chest compressions were significantly improved in saline infusion lambs.
  • Return of spontaneous circulation was achieved in 8/8 lambs receiving epinephrine, compared to 5/10 in the volume infusion group.
  • Assessment involved random allocation of treatments and subsequent monitoring of blood pressure, heart rate, and PaO2 levels.
  • Results indicate that saline infusion during resuscitation may be less effective than intravenous epinephrine in achieving successful outcomes.

Cite This Study

Tran et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c549https://doi.org/10.1136/archdischild-2025-329533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Randomised trial of early rapid saline bolus versus epinephrine during resuscitation in perinatal haemorrhagic cardiac arrest in newborn lambs2026
  2. 2Endotracheal epinephrine at standard versus high dose for resuscitation of asystolic newborn lambs2024 · 12 citations
  3. 3Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study2024 · 6 citations
  4. 4Epinephrine versus saline volume expansion in neonatal resuscitation: a blinded randomized piglet study2026
  5. 5Continuous Chest Compressions with Asynchronous Ventilation in Asphyxiated Preterm Lambs with Asystole2025