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December 8, 2025BMC Pregnancy and ChildbirthOpen Access

The blocking efficacy and safety of tenofovir disoproxil fumarate tablets on mother-to-child transmission in pregnant women with high serum HBV DNA load: a retrospective cohort study

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Authors

XZXu ZhangXQXiaojin QiLLLing Li

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Overview

Retrospective cohort study shows tenofovir disoproxil fumarate improves mother-to-child transmission rates in pregnant women with high HBV DNA levels, indicating favorable safety profile.

Key Points

  • Tenofovir disoproxil fumarate prevents mother-to-child transmission of HBV, enhancing treatment outcomes in high-risk pregnancies.
  • The treatment improves seroconversion rates for HBV DNA, HBeAg, and HBsAg, highlighting its effectiveness in maternal health.
  • Retrospective cohort study design was used to assess the efficacy and safety of tenofovir disoproxil fumarate tablets.
  • The favorable safety profile suggests no severe adverse outcomes, supporting its use in clinical practice.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c77ehttps://doi.org/10.1186/s12884-025-08501-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tenofovir alafenamide or tenofovir disoproxil fumarate in pregnancy to prevent HBV transmission: Maternal ALT trajectory and infant outcomes2024 · 2 citations
  2. 2Chronic HBV : which pregnant women should be treated?2016 · 14 citations
  3. 3The Administration of Tenofovir Disoproxil Fumarate for Pregnant Japanese Women with Chronic Hepatitis B2020 · 4 citations
  4. 4Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and meta-analysis2019 · 16 citations
  5. 5Efficacy and safety of tenofovir disoproxil fumarate or telbivudine used throughout pregnancy for the prevention of mother-to-child transmission of hepatitis B virus: A cohort study2022 · 15 citations