Prospective study shows Type 2 Diabetes Mellitus impairs cognitive performance and increases dementia risk, highlighting mediating inflammatory pathways and biomarkers.
Key Points
Cognitive performance declines with type 2 diabetes mellitus, notably affecting attention and dementia risk.
Poorer attention observed (Hedges' g = −0.15) linked to incident dementia (HR = 2.13) over 15 years.
Analysis of biological pathways through proteomics identifies inflammatory mediators in type 2 diabetes.
Apolipoprotein E and glial fibrillary acidic protein are key biomarkers for predicting dementia.