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December 8, 2025Methods and ProtocolsOpen Access

Identification and Quantitation of 14C-Labeled Catechol Metabolites in Rat Plasma After Intranasal Instillation of Smoldering Eucalyptus Wood Smoke Extract

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Authors

EUEsther A. UbickYKYong Ho Kim

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Overview

Analysis reveals catechol metabolism in rats after smoke exposure, indicating potential for biomarker discovery.

Key Points

  • Catechol metabolites are rapidly formed in circulation following smoke exposure, demonstrating quick metabolism.
  • Identified phenolic compounds were linked to brain and lung health risks from wildfire smoke exposure.
  • Assessment using molecular mass spectrometry provided insights into overall metabolic response to inhaled toxins.
  • Findings highlight potential biomarkers for exposure assessment in respiratory health studies.

Cite This Study

Ubick et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236ca4chttps://doi.org/10.3390/mps8060147
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats2024 · 4 citations
  2. 2Eucalyptus Wood Smoke Extract Elicits a Dose-Dependent Effect in Brain Endothelial Cells2024
  3. 3Robust differential gene expression patterns in the prefrontal cortex of male mice exposed to an occupationally relevant dose of laboratory-generated wildfire smoke2024 · 1 citations
  4. 4B79-14 Functional-immunological Changes in the Lungs of Apoe-/- Mice Following Repeated Exposure to Flaming Eucalyptus-Manzanita Smoke2026
  5. 547 Wildfire surrogate wood smoke particles elicit events linked to premalignant effects in human lung epithelial cells2026