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December 8, 2025Journal of Nuclear MedicineOpen Access

Dynamic Acquisition of 99m TcTc-Pyrophosphate SPECT/CT Images in Transthyretin Cardiac Amyloidosis: A Pilot Study

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Authors

AMAlyssa De MoraesMKMarie Foley KijewskiSCSarah Cuddy

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Overview

Pilot study shows early imaging of Tc-pyrophosphate improves myocardial uptake assessment in ATTR-CM, indicating potential for better diagnosis.

Key Points

  • To determine peak timing of Tc-pyrophosphate uptake and explore early imaging advantages in ATTR-CM.
  • Dynamic SPECT/CT images acquired at multiple time points (0-5 min, 10-65 min)
  • Image analysis using SUVmean, SUVmax, and relative uptake ratios
  • Comparison of ATTR-CM and non-ATTR-CM cohorts
  • Myocardial SUVmean significantly higher at 10 min in ATTR-CM compared to blood pool
  • Early imaging shows stable myocardial uptake in ATTR-CM through 150 min
  • Bone SUVmean peaked at 90 min, suggesting timing importance in imaging

Cite This Study

Moraes et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cd74https://doi.org/10.2967/jnumed.125.270405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early timepoint 99mTc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis2026
  2. 2Quantitative 99mTc-PYP SPECT/CT at 90 minutes improves diagnostic stratification in transthyretin cardiac amyloidosis2026
  3. 3Quantitative single photon emission computed tomography/computed tomography of Tc-99m-pyrophosphate scans: metrics for short-term risk stratification in transthyretin cardiac amyloidosis2026
  4. 4Evaluation of the diagnostic value of dual-time-point, multi-parameter 99mTc-PYP imaging in diagnosing Transthyretin Cardiac Amyloidosis2026 · 1 citations
  5. 5Direct comparison uptake patterns of 99mTc-PYP and 99mTc-HMDP scintigraphy in cardiac amyloidosis with semi-quantitative analysis2026