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December 8, 2025Journal of Ageing and LongevityOpen Access

Polypharmacy and the Use of Potentially Inappropriate Medications in Elderly People in Nursing Homes: A Cross-Sectional Study

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Authors

EPEzequiel PintoAlgarve Biomedical CenterHLHelena S. LeitãoUniversity of Algarve

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Overview

Cross-sectional study shows polypharmacy and PIM use elevate adverse drug events in older adults, indicating a need for medication reviews.

Key Points

  • To describe the sociodemographic and clinical characteristics related to polypharmacy and potentially inappropriate medications (PIM) in elderly nursing home residents.
  • Conducted a cross-sectional descriptive study among 151 residents aged ≥ 65 years
  • Extracted data from institutional records
  • Analyzed the prevalence of polypharmacy and PIM use with binary logistic regression
  • 49.7% of residents exhibited excessive polypharmacy
  • 94% of the sample had potential drug-drug interactions (PDDIs)
  • 82.8% of residents were using potentially inappropriate medications (PIMs)
  • Mean number of medications was 9.66 with nervous system drugs being the most prescribed
  • Identified total number of medications and use of proton pump inhibitors as independent predictors for PIMs

Cite This Study

Pinto et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cd98https://doi.org/10.3390/jal5040054
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Prevalence of Polypharmacy and Potentially Inappropriate Medications and Its Relationship with Cognitive Status in Portuguese Institutionalized Older Adults: A Cross-Sectional Study2022 · 22 citations
  2. 2Potentially Inappropriate Medication: A Pilot Study in Institutionalized Older Adults2024 · 5 citations
  3. 3Potentially Inappropriate Medication: A Pilot Study in Institutionalized Older Adults2024 · 1 citations
  4. 4Polypharmacy and potentially inappropriate medications in older adults who use long-term care services: A cross-sectional study2024
  5. 5Examining potentially inappropriate medication use among elderly individuals in palliative care: A comprehensive study2024 · 2 citations