What question did this study set out to answer?

To evaluate successful fertility preservation strategies for adolescent females with sickle cell anemia undergoing curative therapies.

December 8, 2025BloodOpen Access

Successful fertility preservation during curative therapy in female adolescent sickle cell anemia patients

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Authors

SRStacey Rifkin-ZenenbergHackensack University Medical Center LDLane F. DonnellyUniversity of North Carolina at Chapel Hill

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Implication

Case reports show successful fertility preservation in two adolescents with sickle cell anemia undergoing HSCT or gene therapy, indicating careful management of complications is critical.

Key Points

To evaluate successful fertility preservation strategies for adolescent females with sickle cell anemia undergoing curative therapies.
Case reports of two adolescent females with homozygous SS disease for gene therapy and hematopoietic stem cell transplant.
Implemented a fertility preservation regimen including progestin suppression and gonadotropin dosing.
Facilitated close collaboration between hematology and reproductive endocrinology teams.
Both patients successfully underwent oocyte retrieval without vaso-occlusive crises or thrombotic complications.
Utilized blood transfusions to maintain hemoglobin S% below 30% during fertility preservation process.
Close monitoring allowed for effective management of hemoglobin levels, avoiding serious complications.

Cite This Study

Rifkin-Zenenberg et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfac https://doi.org/10.1182/blood-2025-6531

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Implication

Case reports show successful fertility preservation in two adolescents with sickle cell anemia undergoing HSCT or gene therapy, indicating careful management of complications is critical.

Successful fertility preservation during curative therapy in female adolescent sickle cell anemia patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Successful fertility preservation during curative therapy in female adolescent sickle cell anemia patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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