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December 8, 2025BloodOpen Access

Clinical outcomes in hospitalized sickle cell patients with palliative care consults

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Authors

MCM. J. Crosby

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Overview

Observational study shows higher mortality in hospitalized sickle cell patients receiving palliative care, indicating complex care needs.

Key Points

  • The study aims to evaluate the impact of palliative care consults on hospital outcomes in patients with sickle cell disease.
  • Analysis of National Inpatient Sample (NIS) databases from 2017-2022
  • Identification of patients with primary diagnosis codes for sickle cell disease
  • Comparative analysis between groups with and without palliative care involvement
  • Use of multivariate regression to adjust for confounding factors
  • 437,049 sickle cell disease patients hospitalized from 2017-2022
  • 4,134 received palliative care consults, associated with higher mortality rates (aOR: 24)
  • Hospitalization charges were significantly higher for those with palliative care ($93,000 vs $40,000)
  • Length of stay increased for palliative care consults (10.8 days vs 5.8 days)

Cite This Study

M. J. Crosby (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfbchttps://doi.org/10.1182/blood-2025-6535
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of palliative care in sickle cell disease: A single database literature review of contemporary outcomes data2025
  2. 2Sickle Cell Disease Providers' Perspectives on Palliative Care2024 · 1 citations
  3. 3Retrospective analysis of an inpatient palliative care program2026
  4. 4Disparities in palliative care among hospitalized patients with hematologic malignancies: A National Inpatient Sample analysis (NIS).2025
  5. 5Palliative care consultation reduces hospital costs and length of stay among decedents with hematologic malignancies: A propensity score matched analysis from the national inpatient sample, 2016-20222025