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December 8, 2025BloodOpen Access

Socioeconomic, racial, and hospital-level disparities in inpatient mortality among patients with plasma cell dyscrasias: A 2016-2022 nationwide analysis from the national inpatient sample

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Authors

AFA. Dale FlowersDBDiego Olavarria Bernal

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Overview

Nationwide analysis highlights financial toxicity and racial factors impacting inpatient mortality in plasma cell dyscrasias patients.

Key Points

  • To investigate how socioeconomic and hospital characteristics affect inpatient mortality in plasma cell dyscrasias patients.
  • Conducted retrospective analysis using the National Inpatient Sample (NIS) database from 2016 to 2022.
  • Included adults diagnosed with plasma cell dyscrasias using ICD-10 codes.
  • Utilized multivariable survey-weighted logistic regression model to estimate adjusted odds ratios.
  • Assessed socioeconomic status via ZIP-code–linked income quartiles.
  • Total of 195,384 patients analyzed with a mean age of 68 years.
  • Higher inpatient mortality associated with low income and non-private insurance in plasma cell dyscrasias patients.
  • Charlson Comorbidity Index showed a strong association with mortality risk increase.
  • Racial disparities observed with higher odds of death in non-White racial groups compared to White patients.

Cite This Study

Flowers et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d01ahttps://doi.org/10.1182/blood-2025-8129
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