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December 8, 2025Blood

Single vs double cord blood transplantation: Improved engraftment with comparable efficacy

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Authors

AAAlessandra AzureFGFrédéric GrandjeanNANaveed Ali

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Overview

Retrospective analysis shows improved engraftment with single cord blood transplants in patients, suggesting cost-effectiveness.

Key Points

  • This research aims to compare the outcomes of single versus double cord blood transplantation in patients with hematologic malignancies.
  • Retrospective analysis of 315 patients undergoing their first single or double cord blood transplantation.
  • Utilized myeloablative conditioning regimens with different chemotherapy protocols.
  • Evaluated overall survival, disease-free survival, engraftment, and graft-versus-host disease rates using statistical models.
  • sCBT recipients showed faster engraftment of neutrophils and platelets compared to dCBT.
  • 5-year overall survival was higher in sCBT (70%) than in dCBT (58%).
  • sCBT was associated with lower non-relapse mortality and no difference in relapse rates compared to dCBT.

Cite This Study

Azure et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d03ehttps://doi.org/10.1182/blood-2025-7736
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Avoidance of ATG improves outcomes in double-cord blood transplantation for hematological malignancies2025
  2. 2Single-unit cord blood transplantation reduces the risk of relapse and improves leukemia-free survival compared to other donor sources in allo-HSCT for patients with high-risk acute myeloid leukemia2025
  3. 3Higher survival following transplantation with a mismatched unrelated donor with posttransplant cyclophosphamide‐based graft‐versus‐host disease prophylaxis than with double unit umbilical cord blood in patients with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation2024 · 3 citations
  4. 4Safety and Clinical Outcomes of Pooled Donor, Nonengrafting Expanded Progenitor Cells in Single-Unit Cord Blood Transplantation2026
  5. 5Outcomes of stem cell boost (SCB) versus supportive care alone for prolonged cytopenias after chimeric antigen receptor T cell therapy (CAR-T) in relapsed/refractory multiple myeloma (RRMM): A muli-center real-world analysis2025 · 3 citations