What question did this study set out to answer?

To evaluate the outcomes of double cord blood transplantation (dCBT) when following established guidelines, particularly focusing on the avoidance of anti-thymocyte globulin (ATG).

December 8, 2025Blood

Avoidance of ATG improves outcomes in double-cord blood transplantation for hematological malignancies

View Full Paper

Ask AI

Bookmark

Authors

TWTao WangMedical College of Wisconsin MHMeilun HeNational Marrow Donor Program CBCara L. BenjaminUniversity of Miami

Discussion

Member takes

Implication

Analysis of adherence to guidelines in double cord blood transplants, revealing improved survival and engraftment outcomes without ATG.

Key Points

To evaluate the outcomes of double cord blood transplantation (dCBT) when following established guidelines, particularly focusing on the avoidance of anti-thymocyte globulin (ATG).
Included adult patients who received dCBT for MDS, AML, or ALL between 2010 and 2021.
Compared groups based on adherence to guidelines regarding CD34+ and total nucleated cell (TNC) counts, HLA matching, and product volume.
Evaluated overall survival, disease-free survival, and other clinical outcomes using statistical models.
Significant increase in treatment-related mortality (TRM) associated with ATG use (HR=1.38) and lower, non-significant overall survival (HR 1.25).
Adherence to CD34+ dose lead to significantly improved neutrophil recovery (HR=1.37).
Adherence to volume thresholds improved platelet engraftment (HR=1.17).

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3e1 https://doi.org/10.1182/blood-2025-2436

View Full Paper

Ask AI

Bookmark

Avoidance of ATG improves outcomes in double-cord blood transplantation for hematological malignancies

Discussion

Member takes

Implication

Key Points

Cite This Study

Avoidance of ATG improves outcomes in double-cord blood transplantation for hematological malignancies

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider