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December 8, 2025Blood

Trends in mortality from multiple myeloma and diabetes mellitus in the United States: A retrospective analysis from 1999 to 2020

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Authors

RIRehan IshaqueMYMadhuri YalamanchiliRHRonald M. Harris

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Overview

Retrospective analysis reveals rising mortality trends in diabetic males with multiple myeloma, indicating disparities in survival rates.

Key Points

  • The study aims to analyze trends in mortality from multiple myeloma in patients with diabetes mellitus.
  • Used ICD-10 codes to identify deaths from multiple myeloma in diabetic patients from 1999 to 2020
  • Extracted age-adjusted mortality rates and analyzed trends by gender, race, and year
  • Performed linear regression analysis on the data
  • Total of 18411 deaths from multiple myeloma in diabetic patients from 1999 to 2020
  • Mean AAMR higher for diabetic males (0.527 per 100,000) than females (0.280 per 100,000)
  • Increase in AAMR among diabetic males (β = 0.0066, p < 0.001) but no change in females
  • African American diabetic patients have significantly higher AAMR (1.009) compared to Whites (0.317)
  • No significant change in mortality for African Americans but a slight upward trend in Whites (p = 0.039)

Cite This Study

Ishaque et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d053https://doi.org/10.1182/blood-2025-8132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in death from multiple myeloma with concomitant diabetes mellitus in the USA2025
  2. 2Trends in mortality from multiple myeloma in patients younger than 55 years of age in the United States: A retrospective analysis from 1999 to 20202025
  3. 3Trends in Acute Myeloid Leukemia mortality among patients with diabetes mellitus in the United States, 1999–2024: A CDC wonder database analysis2025
  4. 4Impact of diabetes mellitus on inpatient outcomes among hospitalized patients with multiple myeloma: A National Inpatient Sample analysis (2018–2020).2026
  5. 5Trends and Disparities in Cancer-Related Mortality Among Adults With Diabetes in the United States: 1999-2019.2025 · 1 citations