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December 8, 2025BloodOpen Access

Pre-diagnostic biomarkers show disease susceptibility continuum and enable early prediction of multiple myeloma

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Authors

JXJiadai XuBLBingjie LiZYZhigang Yao

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Overview

Prospective cohort study demonstrates biomarkers predict multiple myeloma in at-risk individuals, highlighting early detection benefits.

Key Points

  • This research aims to identify pre-diagnostic biomarkers that indicate susceptibility to multiple myeloma.
  • Prospective cohort study using UK Biobank data with 501,967 participants.
  • Identified cases of MM through ICD-10 codes and cancer registries.
  • Analyzed eight biomarkers including hemoglobin and kidney function markers.
  • Utilized Cox proportional hazards models for statistical analysis.
  • Examined biomarker patterns across time-stratified onset groups.
  • All eight biomarkers showed significant association with future risk of MM onset.
  • Protein markers had the strongest associations, notably total protein elevation and albumin/globulin reduction.
  • Distinct temporal patterns of biomarker abnormalities were observed across onset groups.
  • Six biomarkers were independently significant in multivariate analysis, achieving a C-index of 0.737.
  • Risk stratification algorithms could enhance early detection and management of MM risk.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0aahttps://doi.org/10.1182/blood-2025-2231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the plasma proteome of multiple myeloma and its precursor conditions and identification of a prognostic high-risk signature of progression2025
  2. 2Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin2025
  3. 3Prognostic impact of early disease progression and early mortality in patients with multiple myeloma: a real-world cohort study2026
  4. 4AI-based analysis reveals novel blood protein biomarkers for predicting cardiac amyloidosis approximately a decade early: A UK biobank study2025
  5. 5Next-Generation Biomarkers in Multiple Myeloma: Advancing Diagnosis, Risk Stratification, and Precision Therapy Beyond Current Guidelines2026 · 2 citations