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December 8, 2025BloodOpen Access

Validation of novel prognostic models in symptomatic Waldenström's macroglobulinemia based on real-world data

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Authors

KMKateřina MenšíkováZAZdeněk AdamDŠDavid Šálek

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Overview

Analysis of prognostic models in symptomatic Waldenström's macroglobulinemia shows chemoimmunotherapy improves survival outcomes.

Key Points

  • To evaluate and validate prognostic models for symptomatic Waldenström's macroglobulinemia using a real-world patient cohort.
  • Included symptomatic WM patients who started first-line treatment from January 2014 to January 2024.
  • Data sourced from Czech Myeloma Registry and Czech Lymphoma Study Group Project.
  • Conducted multivariable analysis on scoring systems and survival analysis using Kaplan-Meier method.
  • Overall response rate was 86% with a median follow-up of 4.8 years.
  • 5-year overall survival probability was 80%, significantly influenced by risk scores and treatment patterns.
  • rIPSSWM showed the best discrimination among risk groups with the highest concordance index.

Cite This Study

Menšíková et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0b0https://doi.org/10.1182/blood-2025-1834
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Also Consider

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  1. 1Prognostic significance of clinical risk models and genomic alterations in Waldenström macroglobulinemia before or after BTK inhibitor era2025
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  3. 3Prognostic impact of comorbidity burden on overall survival in patients with Waldenström macroglobulinemia in the United States.2026
  4. 4Clinical outcomes in newly diagnosed patients with Waldenström's macroglobulinaemia treated in a tertiary academic centre2026 · 1 citations
  5. 5Epidemiology, Real-World Treatment, and Economic Burden of Waldenström Macroglobulinemia: A Comprehensive Analysis Based on Anonymized Claims Data Between 2010 and 20222025