What question did this study set out to answer?

This analysis aims to identify prognostic factors influencing overall survival in Waldenström macroglobulinemia, particularly focusing on comorbidity burden.

May 29, 2026Journal of Clinical Oncology

Prognostic impact of comorbidity burden on overall survival in patients with Waldenström macroglobulinemia in the United States.

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Authors

GHGaelle HaddadCleveland Clinic Florida HLHong LiangCleveland Clinic Florida CFChieh Lin FuCleveland Clinic Florida

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Implication

Retrospective analysis demonstrates that comorbidity burden significantly affects survival in Waldenström macroglobulinemia, suggesting improved prognostic models are necessary.

Key Points

This analysis aims to identify prognostic factors influencing overall survival in Waldenström macroglobulinemia, particularly focusing on comorbidity burden.
Retrospective study of 17130 patients with confirmed Waldenström macroglobulinemia from NCDB (2004–2023).
Univariable and multivariable Cox regression analyses conducted to identify independent prognostic factors.
Age-stratified sub-analysis performed to assess comorbidity impacts on survival within different age groups.
Charlson comorbidity score (CC) ≥1 was identified as a strong independent predictor of mortality (HR 1.7, 95% CI 1.58–1.75, p<0.0001).
Advanced age was increasingly associated with worse survival across age groups (HR range 1.7 to 5.5, all p<0.0001).
Female sex, private insurance status, and treatment at academic centers positively influenced survival outcomes.

Cite This Study

Haddad et al. (2026) studied this question.

synapsesocial.com/papers/6a192dbbfab5b468c4416ad2 https://doi.org/10.1200/jco.2026.44.16_suppl.7083

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Implication

Retrospective analysis demonstrates that comorbidity burden significantly affects survival in Waldenström macroglobulinemia, suggesting improved prognostic models are necessary.

Prognostic impact of comorbidity burden on overall survival in patients with Waldenström macroglobulinemia in the United States.

Discussion

Member takes

Implication

Key Points

Cite This Study

Prognostic impact of comorbidity burden on overall survival in patients with Waldenström macroglobulinemia in the United States.

Discussion

Member takes

Implication

Key Points

Cite This Study

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