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December 8, 2025BloodOpen Access

Multiple myeloma genetic alterations have distinct repertoires and prognostic implications in African and european ancestries

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Authors

VGVikas A. GuptaEmory UniversityNJNisha S. JosephEmory UniversityANAjay K. NookaEmory University

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Implication

Analysis reveals distinct genetic alterations in multiple myeloma, indicating ancestry influences prognosis in Black and White patients.

Key Points

  • The aim is to explore differences in genetic alterations and their prognostic implications in multiple myeloma based on ancestry.
  • Analyzed data from 977 patients treated with RVD1000 using self-identified race and genomic sequencing data.
  • Used Whole Genome Sequencing and statistical tests to assess genetic differences in ancestry groups.
  • Evaluated prognosis via Kaplan-Meier survival analysis and Cox proportional hazards models.
  • No difference in PFS or OS between Black and White patients with multiple myeloma.
  • Black patients showed a lower overall mutational burden and fewer specific mutations in TP53 and IRF4.
  • Certain translocations conferred worse outcomes in African ancestry patients, suggesting ancestry-specific risk modifiers.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0d6https://doi.org/10.1182/blood-2025-2251
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutation landscape and pathway-level disparities in Black versus White patients with acute myeloid leukemia.2026
  2. 2Genomic Features Do Not Account for Differences in Multiple Myeloma Risk by Ancestry2026
  3. 3Inferior survival in black AML patients treated with intensive chemotherapy in ECOG-ACRIN clinical trials is independent of cytogenetic profiles2025
  4. 4Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  5. 5Abstract 3994: Differences in the mutational landscape across race and sex highlight distinct TP53-associated risk in multiple myeloma2026