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December 8, 2025BloodOpen Access

Inferior survival in black AML patients treated with intensive chemotherapy in ECOG-ACRIN clinical trials is independent of cytogenetic profiles

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Authors

SFShella Saint Fleur-LominyZSZhuoxin SunFGFrancine E. Garrett-Bakelman

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Overview

Observational study shows racial disparities in survival outcomes for AML, indicating a need for tailored approaches.

Key Points

  • To analyze survival outcomes based on race in acute myeloid leukemia (AML) patients treated with chemotherapy.
  • Utilized ECOG-ACRIN data from adult AML patients over three decades.
  • Categorized self-reported race as White, Black, or Other for analysis.
  • Employed multivariable Cox proportional hazards regression models to assess survival outcomes.
  • Black race was an independent prognostic factor for inferior overall survival and disease-free survival.
  • No significant racial differences were found in cytogenetic profiles, despite younger age at diagnosis for Black patients.
  • NPM1 mutations were associated with inferior overall survival in Black compared to White patients.

Cite This Study

Fleur-Lominy et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d706https://doi.org/10.1182/blood-2025-290
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  2. 2Molecular landscape and outcomes of Black and White adults diagnosed with acute myeloid leukemia.2026
  3. 3Mutation landscape and pathway-level disparities in Black versus White patients with acute myeloid leukemia.2026
  4. 4Impact of race on mutational profile and survival in acute myeloid leukemia: a single-institution experience (2014–2024)2026
  5. 5Abstract 2486: Racial differences in clinical and cytogenetic features of pediatric acute myeloid leukemia2026