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December 8, 2025Blood

Rethinking disparity in Acute Myeloid Leukemia, a new perspective in the Asian population

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Authors

WXWenbin XiaoESEytan M. Stein

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Overview

Observational study reveals racial/ethnic disparities in survival outcomes for Asian versus White AML patients, suggesting enhanced risk stratification is needed.

Key Points

  • To examine disparities in outcomes between Asian and White patients with newly diagnosed acute myeloid leukemia (AML) and explore underlying genomic differences.
  • Retrospective analysis of adult patients with newly diagnosed AML at Memorial Sloan Kettering Cancer Center.
  • Patients self-identified as White or Asian and underwent genomic workup with MSK-IMPACT HEME.
  • Overall survival was analyzed using Kaplan-Meier method and Cox regression modeling.
  • Asian patients had a median overall survival of 64.6 months compared to 21.5 months for White patients (p=0.01).
  • Younger median age at diagnosis observed in Asians (58 years) compared to Whites (66 years).
  • Asian patients classified as 'adverse risk' had better outcomes than historical data from primarily White populations.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5efhttps://doi.org/10.1182/blood-2025-38
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  2. 2Disaggregated outcomes of Asian Americans, Native Hawaiian and Pacific Islander populations with Acute Myeloid Leukemia2025
  3. 3Inferior survival in black AML patients treated with intensive chemotherapy in ECOG-ACRIN clinical trials is independent of cytogenetic profiles2025
  4. 4Abstract 2486: Racial differences in clinical and cytogenetic features of pediatric acute myeloid leukemia2026
  5. 5Molecular landscape and outcomes of Black and White adults diagnosed with acute myeloid leukemia.2026