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December 8, 2025BloodOpen Access

Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)

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Authors

PPPujan PatelJSJinming SongRSRory M. Shallis

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Overview

Retrospective analysis reveals worse survival outcomes for Black AML patients compared to White and Hispanic, highlighting genomic disparities.

Key Points

  • To explore racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML).
  • Retrospective study on AML patients at Moffitt Cancer Center
  • Patients categorized by race: Black, Hispanic, White
  • Used Kaplan-Meier analysis and log-rank test to estimate overall survival
  • Black and Hispanic patients were younger than Whites at diagnosis
  • Black patients had shorter overall survival compared to Whites
  • Notable differences in mutations were observed, particularly for TP53 and ETV6

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d367https://doi.org/10.1182/blood-2025-4630
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