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December 8, 2025Blood

An analysis of the mutational landscape of Acute Myeloid Leukemia at an urban tertiary care center: A retrospective cohort study

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Authors

SRSyed Shahrukh RizviAWAlexander WillisJLJessie Li

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Overview

Retrospective cohort analysis identifies racial disparities and DNMT3A mutations in acute myeloid leukemia.

Key Points

  • The study aims to analyze the mutational landscape of acute myeloid leukemia (AML) and its association with demographic factors.
  • Retrospective data collection from AML patients at a university cancer center
  • Involvement of demographic data like race, ethnicity, age, and gender
  • Utilization of Microsoft Excel for data analysis
  • Identified DNMT3A mutations as common in the cohort
  • Noted significant racial disparities in genetic profiles
  • Average age of diagnosis was lower than previously reported

Cite This Study

Rizvi et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2c0https://doi.org/10.1182/blood-2025-7037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5301: Evaluating the molecular landscape of genetic mutations among Black patients with acute myeloid leukemia2026
  2. 2Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  3. 3Molecular landscape and outcomes of Black and White adults diagnosed with acute myeloid leukemia.2026
  4. 4Mutation landscape and pathway-level disparities in Black versus White patients with acute myeloid leukemia.2026
  5. 5Impact of race on mutational profile and survival in acute myeloid leukemia: a single-institution experience (2014–2024)2026