Observational study links IKZF1plus genotype and ABL1 mutations with mortality in adult BCR::ABL1-positive ALL, suggesting improved risk stratification and treatment outcomes.
Key Points
To investigate the association of IKZF1plus genotype and ABL1 mutations with clinical outcomes in adult BCR::ABL1-positive acute lymphoblastic leukemia.
Patients aged ≥18 with newly diagnosed BCR::ABL1-positive ALL were recruited.
IKZF1plus genotyping and ABL1 mutation analysis were performed using MLPA and PCR.
Overall survival rates were assessed with respect to IKZF1plus and ABL1 mutation status.
IKZF1plus genotype showed significant correlation with mortality rates among patients with T315I mutations.
Overall survival rates were markedly lower in IKZF1plus/T315I subgroup compared to other groups.
Allo-HSCT improved survival rates in patients with IKZF1plus/T315I mutations.