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December 8, 2025BloodOpen Access

Leveraging an integrated single cell atlas to understand perinatal bone marrow development

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Authors

JGJames GarifallouFSFangfang SongFLFanxin Long

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Overview

Integrated dataset shows dynamic changes in gene expression in perinatal bone marrow, indicating distinct hematopoietic niche drivers.

Key Points

  • This research focuses on understanding the development of the hematopoietic niche during the perinatal phase in mouse bone marrow.
  • Generated single cell atlas with scRNAseq data from late gestation to aged adult mice
  • Performed dataset integration using Harmony and canonical correlation analysis
  • Conducted cell clustering to identify distinct cell populations
  • Identified significant changes in gene expression during perinatal development
  • Observed that CAR cells and progenitors expand postnatally
  • Noted distinct transcription factor activity patterns between fetal and postnatal marrow

Cite This Study

Garifallou et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d25bhttps://doi.org/10.1182/blood-2025-1412
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth2024 · 7 citations
  2. 2A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche2025 · 1 citations
  3. 3Editorial: Plasticity of the haematopoietic niche: from embryonic development to aging and disease2025 · 2 citations
  4. 4Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling2026 · 3 citations
  5. 5Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution2024 · 4 citations