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Evaluate the impact of intravenous iron on mortality in sepsis patients with iron deficiency anemia.

December 8, 2025Blood

Intravenous iron administration during sepsis: Outcomes, safety, and hemoglobin response

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Retrospective cohort study shows IV iron improves survival in sepsis patients with anemia, suggesting effective management strategies.

Evaluate the impact of intravenous iron on mortality in sepsis patients with iron deficiency anemia.
Retrospective cohort study using TriNetX database
Included 34,040 patients with sepsis and iron deficiency anemia
Utilized propensity score matching to address confounders
IV iron linked to reduced mortality at 14, 30, 60, and 90 days.
14-day mortality: 4.4% in IV iron vs. 7.9% controls; RR 0.55; p < 0.0001.
30-day mortality: 8.2% in IV iron vs. 12% controls; RR 0.70; p < 0.0001.
60-day mortality: 11.0% in IV iron vs. 16% controls; RR 0.74; p < 0.0001.

Omar et al. (2025) studied this question.

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