What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

This research aims to evaluate the efficacy and safety of azacitidine combined with LDAC in frail elderly patients with acute myeloid leukemia.

December 8, 2025BloodOpen Access

Efficacy and safety of azacitidine plus LDAC in newly diagnosed, frail elderly patients with Acute Myeloid Leukemia

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This research aims to evaluate the efficacy and safety of azacitidine combined with LDAC in frail elderly patients with acute myeloid leukemia.
Prospective phase 2 clinical trial
Enrolled 38 patients aged ≥ 60 years ineligible for intensive chemotherapy
Treatment regimen involved subcutaneous azacitidine and LDAC in 28-day cycles
Primary endpoint: overall response rate; secondary endpoints: overall survival, duration of response, safety.
Overall response rate was 50% (19 out of 38 patients)
Median overall survival was 22.5 months
Febrile neutropenia occurred in 47.3% of patients
Molecular profiling showed TP53 mutations in 15.8% of patients

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Implication

Clinical trial demonstrates azacitidine plus LDAC improves overall response rate in frail elderly AML patients, suggesting a promising treatment option.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d37e https://doi.org/10.1182/blood-2025-6983

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Implication

Clinical trial demonstrates azacitidine plus LDAC improves overall response rate in frail elderly AML patients, suggesting a promising treatment option.

Efficacy and safety of azacitidine plus LDAC in newly diagnosed, frail elderly patients with Acute Myeloid Leukemia

Key Points

Discussion

Implication

Cite This Study

Efficacy and safety of azacitidine plus LDAC in newly diagnosed, frail elderly patients with Acute Myeloid Leukemia

Key Points

Discussion

Implication

Cite This Study

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