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This research aims to understand the role of cellular senescence in immune dysfunction and myeloma persistence linked to aging.

December 8, 2025BloodOpen Access

Cellular senescence associated with aging and chemotherapy exposure primes bone marrow for immune dysfunction and myeloma persistence

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This research aims to understand the role of cellular senescence in immune dysfunction and myeloma persistence linked to aging.
Created a multi-omics atlas using single-cell RNA sequencing and spatial transcriptomics.
Collected bone marrow samples from 65 donors aged 25-90 during orthopedic surgeries.
Analyzed over 300,000 cells to characterize hematopoietic stem/progenitor cells and stromal cell dynamics.
Identified age-related increases in cell cycle arrest markers in HSPC subpopulations.
Observed elevated senescence markers in stromal cells near stem cells in older individuals.
Found increased expression of immune exhaustion markers in treated multiple myeloma samples.

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Multi-omics analysis reveals cellular senescence promotes immune dysfunction in bone marrow related to myeloma.

Wang et al. (2025) studied this question.

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