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December 8, 2025BloodOpen Access

Transfusion dependence is associated with poor survival in MDS-h and MDS-LB, while transplantation improves outcomes

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Authors

HWHui WangEJErlie JiangZXZhijian Xiao

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Overview

Retrospective analysis shows transfusion dependence worsens survival in MDS-h and MDS-LB, suggesting allo-HSCT improves outcomes.

Key Points

  • Evaluate the relationship between transfusion dependence and survival in MDS-h and MDS-LB patients.
  • Retrospective analysis of 636 patients with MDS-h and MDS-LB
  • Assessment of transfusion dependence at diagnosis
  • Evaluation of mutations and risk classification
  • Transfusion dependence at diagnosis linked to lower overall survival (HR=3.271)
  • Common mutations included U2AF1 and ASXL1
  • Allogeneic stem cell transplantation improved survival outcomes for transfusion-dependent patients

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3f5https://doi.org/10.1182/blood-2025-7381
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