Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Disrupting CXCL12-DPP4-GPC3 axis redistributes leukemia stem cells and confines AML cells within bone marrow niche

View Full Paper
Ask AI
Bookmark
Share

Authors

WZWenxuan ZhouLLLinheng Li

Discussion

Loading...

Member takes

Overview

Targeted disruption of CXCL12-DPP4-GPC3 axis alters leukemia stem cell distribution and reduces AML dissemination.

Key Points

  • This research aims to understand how spatial organization in bone marrow influences leukemia stem cell behavior in acute myeloid leukemia.
  • Utilized murine AML models with genetic manipulation of Dpp4, Cxcl12, and Gpc3.
  • Conducted analyses using flow cytometry, immunofluorescence microscopy, and cytokine profiling.
  • Performed functional transplantation assays and single-cell RNA sequencing on stromal compartments.
  • LSCs localize preferentially to proximal and distal metaphysis, showing quiescence and high leukemogenic potential.
  • Dpp4 deletion disrupts CXCL12 gradient, causing LSC redistribution to the central marrow, increasing proliferation and apoptosis.
  • Identified N-cadherin⁺ MSCs as primary Cxcl12-expressing niche population in metaphysis.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d41bhttps://doi.org/10.1182/blood-2025-658
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour2026
  2. 2Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression2024
  3. 3Abstract P07: Identification of the unique preleukemic bone marrow niche in acute myeloid leukemia2024 · 1 citations
  4. 4Leukemic stem cell–niche interaction through CLEC2-podoplanin axis confers drug resistance in acute myeloid leukemia2026
  5. 5Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy2025 · 2 citations