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December 8, 2025BloodOpen Access

MPN with multiple driver clones show distinct patterns of therapy response and progression - “MPN double driver”

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Authors

TSTina M. SchnoederMedizinische Hochschule HannoverFPFrancesca PalandriIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'OrsolaFBFilippo BranzantiUniversity of Cagliari

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Overview

Observational study shows double driver mutations impact survival and therapy response in myeloproliferative neoplasms.

Key Points

  • To characterize the clinical management and molecular landscape of myeloproliferative neoplasms with double driver mutations.
  • Analyzed 84,921 samples for mutations in JAK2, CALR, and MPL.
  • Examined cohorts from international patient groups and the German MPN Study Group Registry.
  • Investigated therapy responses in 56 double driver patients with detailed clinical annotation.
  • 1.5% of individuals harbored at least 2 mutations, with variable clone sizes and mutation combinations.
  • Patients with double driver mutations had higher rates of progression to myelofibrosis than those with single mutations.
  • Therapy responses to interferon-alpha showed partial and complete molecular responses for MPL-clones.

Cite This Study

Schnoeder et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d41chttps://doi.org/10.1182/blood-2025-1021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical features and outcomes of myeloproliferative neoplasm patients with MPL mutations and concurrent JAK2/calr mutations2025
  2. 2Clinical and genetic features of Ph-negative myeloproliferative neoplasms with dual-driver gene positivity2026
  3. 3Mutational Analysis of Driver and Non-driver Mutations of Philadelphia Chromosome-negative Myeloproliferative Neoplasms; Diagnosis and Recent Advances in Treatment2024
  4. 4Prevalence and clinicopathological features of driver gene mutations profile in BCR: ABL1 negative classical myeloproliferative neoplasm—A single-center study from North India2024 · 1 citations
  5. 5Clinical laboratory characteristics and gene mutation spectrum of <i>Ph</i>‐negative <scp>MPN</scp> patients with atypical variants of <i>JAK2</i>, <i>MPL</i>, or <i>CALR</i>2024 · 3 citations