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December 8, 2025BloodOpen Access

Myeloproliferative neoplasm driver mutations (JAK2/CALR/MPL) in chronic myelomonocytic leukemia are associated with an increased risk of blast transformation

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Authors

SFSaubia FathimaMayo ClinicAAAli AlsugairMayo Clinic in ArizonaTLTerra L. LashoMayo Clinic

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Overview

Observational study reveals that myeloproliferative neoplasm mutations raise blast transformation risk in chronic myelomonocytic leukemia, suggesting implications for patient management.

Key Points

  • This research aims to evaluate the impact of myeloproliferative neoplasm driver mutations on blast transformation and overall survival in chronic myelomonocytic leukemia patients.
  • Retrospective analysis of patient data under IRB-approved protocols.
  • Diagnostic criteria followed the International Consensus Classification.
  • Statistical analyses performed using JMP Pro and Bluesky Statistics Software.
  • 56 out of 612 patients showed myeloproliferative neoplasm mutations, with higher rates of absolute neutrophil count and leukocytosis.
  • Blast transformation occurred in 19% of patients, with increased risk associated with mutations.
  • Overall survival showed no significant difference between patients with and without these mutations.

Cite This Study

Fathima et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d79dhttps://doi.org/10.1182/blood-2025-2067
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CMML2AML: Machine-learning discovery of co-mutations predictive of blast transformation in chronic myelomonocytic leukemia2025
  2. 2Clinical features and outcomes of myeloproliferative neoplasm patients with MPL mutations and concurrent JAK2/calr mutations2025
  3. 3CMML2AML: machine-learning discovery of co-mutations and specific single mutations predictive of blast transformation in chronic myelomonocytic leukemia2026 · 1 citations
  4. 4Clinical features and outcomes of myelofibrosis patients with MPL mutations2025
  5. 5Risk-adjusted comparison of survival in chronic myelomonocytic leukemia with and without allogeneic stem cell transplant: Mayo Clinic experience in 775 consecutive patients2025