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December 8, 2025BMJ Supportive & Palliative Care

Mirtazapine and olanzapine for cancer-related psychological distress in advanced oral cancer: efficacy and safety prospective study

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Authors

SPSurendra Kumar PingoliyaPRPavan Gaurav R

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Overview

Prospective study shows mirtazapine and olanzapine reduce anxiety and depression in oral cancer, suggesting mirtazapine may be preferred.

Key Points

  • To evaluate and compare the efficacy and safety of olanzapine and mirtazapine in managing psychological distress in oral cavity cancer.
  • 144 patients were randomly allocated into two groups: Group M (mirtazapine) and Group O (olanzapine)
  • Mirtazapine was administered at 15 mg/day; Olanzapine at 5 mg/day orally at bedtime
  • Psychological distress was assessed using the Hospital Anxiety and Depression Score at baseline, and at 2 and 4 weeks follow-up.
  • Both drugs significantly reduced anxiety and depression scores over time with p<0.001
  • Mirtazapine reduced anxiety scores from 14.10 to 10.28 and depression from 14.07 to 10.24
  • Olanzapine reduced anxiety scores from 14.08 to 10.97 and depression from 14.01 to 10.98

Cite This Study

Pingoliya et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4bbhttps://doi.org/10.1136/spcare-2025-005706
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