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December 8, 2025Blood

Retention of immunosuppressive C1Q macrophages following therapeutic interventions imparts negative outcomes across human multiple myeloma studies

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Authors

JEJoshua EpsteinCSChang-Xin ShiKPKirsten Pfeffer

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Overview

Single-cell analyses reveal C1Q macrophages affect clinical outcomes in multiple myeloma, implying immune resistance mechanisms.

Key Points

  • The study aims to investigate the role of C1Q macrophages in multiple myeloma and their clinical implications after therapeutic interventions.
  • Integrated data from 56 human bone marrow samples and three public datasets using Seurat for single-cell analysis
  • Explored cellular compositions and functional relationships among cell populations
  • Applied multivariate Cox survival analysis to assess associations between C1Q expression and clinical outcomes.
  • Identified a consistent cluster of C1Q-expressing macrophages in all analyzed cohorts
  • Noted distinct expression features in progressive disease phases
  • High C1Q expression correlated with inferior overall survival in post-baseline samples.

Cite This Study

Epstein et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4cehttps://doi.org/10.1182/blood-2025-7481
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Also Consider

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  1. 1Surface protein-focused gene expression analysis identifies prognostic immunophenotypes in newly diagnosed multiple myeloma2025
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  3. 3Kinetics of circulating multiple myeloma cells (CMMCs) in patients undergoing standard-of-care anti-BCMA chimeric antigen receptor T cell therapy for Relapsed/Refractory multiple myeloma2025 · 1 citations
  4. 450 Tumor–Myeloid Multicellular Programs Reveal ECM-Associated Macrophage Polarization in ccRCC2026
  5. 5Abstract 6881: Investigating the role of post-transplant bone marrow immune dysregulation in multiple myeloma2024