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December 8, 2025BloodOpen Access

Spatial multiomics reveal a critical role for TIM4-expressing macrophages in blast transformation of chronic myelomonocytic leukemia

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Authors

AMAbhishek A. MangaonkarJVJosé C. VillasboasCTChristy E. Trussoni

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Overview

Spatial multiomics reveals macrophages contribute to CMML progression and immune interactions, indicating blast transformation may be linked to TIM4 expression.

Key Points

  • This research aims to explore how macrophages and immune cells in the bone marrow microenvironment influence chronic myelomonocytic leukemia progression.
  • Used spatial multiomics to analyze archival bone marrow samples from CMML patients.
  • Conducted spatial transcriptomics with GeoMx Digital Spatial Profiler and flow cytometry for validation.
  • Analyzed cell interactions and phenotyping through multiplex imaging and statistical correction methods.
  • Documented increased TIMD4 expression in macrophages in chronic myelomonocytic leukemia.
  • Observed significant interactions between macrophages and immune cells, influencing leukemia transformation.
  • Identified key genes associated with immune cell interactions in the bone marrow.

Cite This Study

Mangaonkar et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d82ehttps://doi.org/10.1182/blood-2025-3831
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  1. 1Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia2025
  2. 2High-Dimensional Spatiotemporal Single-Cell Atlas and 3D imaging of Bone Marrow Microenvironment during CML Progression.2026
  3. 3High-Dimensional Spatiotemporal Single-Cell and 3D Atlas of the Bone Marrow Microenvironment during Leukemic Progression2025 · 1 citations
  4. 4Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions2025
  5. 5Abstract B050: Spatial Investigation of CD4+ T-cell priming during leukemia initiation2026