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December 8, 2025Blood

Development of a novel LRP1 antibody that identifies upregulation of membrane LRP1 on activated and chimeric antigen receptor T cells

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Authors

TYTian-Hui Yang

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Implication

Monoclonal antibodies reveal high LRP1 expression in activated CD4 and CD8 T cells, indicating their role in cell signaling and lipid metabolism.

Key Points

  • To develop a high-affinity monoclonal antibody to characterize LRP1 expression on T cells.
  • Developed monoclonal antibodies against LRP1 using recombinant protein as immunogen.
  • Performed binding affinity analysis via enzyme-linked immunoassays and Octet assay.
  • Examined LRP1 expression on T cells using flow cytometry after activation with CD3/CD28.
  • Identified a high-affinity antibody, 2A7, specifically binding to LRP1.
  • LRP1 expression increased significantly on activated CD4+ and CD8+ T cells over time.
  • Found higher LRP1 levels on effector and central memory T cells and CAR-T cells compared to naïve T cells.

Cite This Study

Tian-Hui Yang (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4f9https://doi.org/10.1182/blood-2025-7637
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