What question did this study set out to answer?

To evaluate the prognostic impact of the simplified hlama score and its association with treatment-related complications in primary gastric lymphoma.

December 8, 2025Blood

Prognostic impact of the simplified hlama score and treatment-related complications in primary gastric diffuse large b-cell lymphoma: A retrospective study from a latin American center

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Retrospective study finds simplified hlama score correlates with adverse events in gastric lymphoma patients, suggesting better risk stratification.

To evaluate the prognostic impact of the simplified hlama score and its association with treatment-related complications in primary gastric lymphoma.
Retrospective observational study of adults diagnosed with primary gastric lymphoma at a Latin American center.
Risk stratification based on sHLAMA score (hemoglobin <10.5 g/dL, LDH ≥300 U/L, age ≥75 years).
Overall survival estimated using Kaplan-Meier method; adverse events recorded and correlated with survival outcomes.
32 patients included; median age was 57.7 years, with 65.6% having ECOG performance status >2.
6- and 12-month overall survival rates were 78.1% and 61.7%, respectively.
High-risk patients had significantly reduced OS rates, indicating a strong association between sHLAMA score and gastric perforation.

Omar Fernández Vargas (2025) studied this question.

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Retrospective study finds simplified hlama score correlates with adverse events in gastric lymphoma patients, suggesting better risk stratification.