What question did this study set out to answer?

To evaluate clinical and epidemiological aspects of primary gastrointestinal lymphomas in Brazil.

December 8, 2025BloodOpen Access

Analysis of lymphoma subtypes, involved sites, and treatment outcomes in primary gastrointestinal B-cell lymphomas: A subset analysis within the PELÉ study of brazilian centers.

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Retrospective analysis shows lymphoma types and treatment outcomes in Brazilian centers, indicating challenges for management.

To evaluate clinical and epidemiological aspects of primary gastrointestinal lymphomas in Brazil.
Retrospective, multicenter observational study across Brazilian centers from 2009 to 2024
Review of cases categorized by gastrointestinal site and clinical stages
Data management using the REDCap platform
Statistical analysis performed with IBM SPSS v.24
Survival estimates calculated with Kaplan-Meier method and Cox regression models for prognostic factors
206 patients included, median age at diagnosis 63 years, mostly white (68.4%) and male (55.8%)
Stomach was the most common involvement site (72.3% of cases) with DLBCL (55.3%) and MZL (40.8%) as main subtypes
Complete remission rate of 73% for DLBCL with rituximab-based therapy, while radiotherapy achieved a 76% histological remission rate for gastric MZL cases
5-year event-free survival was 76% for DLBCL and 81% for MZL, with better outcomes in gastric DLBCL patients compared to gastric MZL patients

Silveira et al. (2025) studied this question.

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